ACTH receptor
نویسندگان
چکیده
منابع مشابه
The expression of the ACTH receptor.
Adrenal glucocorticoid secretion is regulated by adrenocorticotropic hormone (ACTH) acting through a specific cell membrane receptor (ACTH-R). The ACTH-R is a member of the G protein superfamily-coupled receptors and belongs to the subfamily of melanocortin receptors. The ACTH-R is mainly expressed in the adrenocortical cells showing a restricted tissue specificity, although ACTH is recognized ...
متن کاملMelanocortin 4 receptor becomes an ACTH receptor by coexpression of melanocortin receptor accessory protein 2.
Melanocortin 2 receptor (MC2R) is the only canonical ACTH receptor. Its functional expression requires the presence of an accessory protein, known as melanocortin receptor 2 accessory protein 1 (MRAP1). The vertebrate genome exhibits a paralogue gene called MRAP2, which is duplicated in zebrafish (MRAP2a and MRAP2b), although its function remains unknown. In this paper, we demonstrate that MRAP...
متن کاملACTH-receptor expression, regulation and role in adrenocortial tumor formation.
The regulation of the ACTH-receptor gene is unique in that it is up-regulated by its own ligand, ACTH. Ligand-induced up-regulation of ACTH-receptor expression may be an important adaptive process directed towards optimizing adrenal responsiveness to ACTH in the context of physiological stress and the maintenance of metabolic homeostasis in which the adrenals play a pivotal role. Whereas enhanc...
متن کاملRole of ACTH receptor in adrenocortical tumor formation.
Adrenocorticotrophin (ACTH) is the major regulatory hormone of steroid synthesis and secretion by adrenocortical cells. The actions of ACTH are mediated by its specific membrane receptor (ACTH-R). The human ACTH-R gene was recently cloned, allowing systematic determination of its sequence, expression and function in adrenal tumorigenesis. The presence of oncogenic mutations of the ACTH-R gene i...
متن کاملACTH (corticotropin)-receptor mediated events in the adrenocortical cell membrane.
Tsushima, T., Sasaki, N., lmai, Y., Matsuzaki, F. & Friesen, H. G. Wallis, M. (1981) in Cellular Receptors for Hormones and (1980) Biochem. J . 187,479-492 Neurotransmitters (Schulster, D. & Levitski, A., eds.), pp 163-183. Wallis, M. (1975) Biol. Rev. 50, 35-98 Wiley, Chichester Wallis, M. (1978) in Chemistry and Biochemistry of Amino Acids, Wallis, M., Surowy, T. K., Daniels, M., Hartree, A. ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1978
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)67030-7